Plants have evolved an array of cascade interactions as the first line of defense to respond to biotic and abiotic stresses. Osmotin is a stress-responsive plant protein belonging to pathogenesis-related (PR)-5 family. Because of its structural and functional similarity to adiponectin, an insulin sensitizing hormone, it has gained much interest. We hypothesize that osmotin may affect the same signaling pathway as adiponectin and may have a possible role in associated malignancies, similar to that of adiponectin. My work primarily focuses on the purification of the osmotin protein from disease resistant wild pepper-Piper colubrinum and further analysis of its role in modulating key pathways regulated by adiponectin in suitable cancer cell models.
Deepthi S, PhD
Andrographis paniculata, commonly known as ‘Kalmegh’ or ‘Nilavembu’, is a perennial herbaceous medicinal plant. The therapeutic activity of A. paniculata has been attributed to Andrographolide, a bicyclic diterpenoid lactone present in the whole plant. Microbial symbionts are reported to promote biomass and secondary metabolite production in plants through nutrient acquisition, growth promotion, and protection against biotic and abiotic stresses. Piriformospora indica is an axenically cultivable phytopromotional and wide-host root-colonizing endosymbiotic fungus with many biotechnological applications including enhancement of growth and secondary metabolite production in plants. My work is focused on co-cultivating in vitro cultures of A. paniculata and P. indica to analyse the molecular effects of P. indica co-cultivation leading to the changes in Andrographolide production. The work also extends to fractionation of cell wall extract of P. indica to identify the active cell wall fractions which can induce enhanced Andrographolide production.
Identification and functional characterization of pathogenic effectors from the oomycete Phytophthora capsici Leonian.
Elucidation of functional roles of key secondary metabolite pathway genes in Piper nigrum L : Exploring the potential of 'priming' as a possible crop protection strategy.
Identification and functional characterization of Phytophthora capsici effectors specific to 'quick wilt' disease in black pepper (Piper nigrum).
Transcriptome analysis and characterization of key metabolic and hormone signalling pathway genes in Piper nigrum in response to defense elicitors.
Gayathri G S
Laboratory management assistance.
Rajiv Gandhi Centre for Biotechnology (RGCB), Thycaud Post,
Poojappura, Thiruvananthapuram - 695 014, Kerala, India +91-471-2529400
| 2347975 | 2348753 +91-471-2348096