Renjini A.P, PhD
Post-doctoral Fellow
Deciphering the role of ER alpha in modulating the strength of STAT3
function
Steroid signaling during window of implantation becomes
indispensible for defining unique molecular signatures and protein
networks. The uterus and the blastocyst perform dynamic homework to
achieve implantation. The steroid hormone estrogen is crucial for the
process of implantation and epithelial proliferation as it specifies the
duration of the window of uterine receptivity for implantation. ERa, the
mediator of estrogen action, is the predominant form in the murine
uterus. Signal transducer and activator of transcription 3 (STAT3) is a
key transcription factor during implantation acting as mediator of
various cytokines. ERa interaction with STAT3 has been well documented
in cancer. In this project we would try to see whether STAT3 associates
with ERa, identify if the LXXLL Motif in STAT3 is responsible for this
interaction and decipher the functional significance of ER-STAT3
interaction during embryo implantation.
