Metformin attenuates effects of cyclophilin A on macrophages, reduces lipid uptake and secretion of cytokines by repressing decreased AMPK activity.

Ramachandran S, Anandan V, Kutty VR, Mullasari A, Pillai MR, Kartha CC. (2018)
Clinical Science     132(6):719-38.

Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions; a cellular mechanism for accelerated macro vascular disease in diabetes mellitus.

Ramachandran S, Vinitha A, CC Kartha. (2016)
Cardiovascular Diabetology     15(1):152.

PPIA rs6850: A > G single-nucleotide polymorphism is associated with raised plasma cyclophilin A levels in patients with coronary artery disease.

Vinitha A, Kutty VR, Vivekanand A, Reshmi G, Divya G, Sumi S, Santosh KR, Pratapachandran NS, Ajit MS, Kartha CC, Ramachandran S*. (2015)
Mol Cell Biochem.     412(1-2):259-6 *Corresponding author

Nonsynonymous T280M gene variant of CX3CR1 in South Indian population is associated with reduced risk for vascular disease in diabetes mellitus.

S Sumi*, S Ramachandran*, VR Kutty, MM Patel, T Anand, A Mullassari, CC Kartha (*Equal first author) (2015)
Current Research Cardiology     4:188-192

Plasma level of cyclophilin A is increased in patients with type 2 diabetes mellitus and suggests presence of vascular disease.

Ramachandran S, Venugopal A, Ramankutty V, Vinitha A,Divya G, V Chitrasree, AjitMullassari, N S PratapChandran, K R Santosh, M Radhakrishna Pillai, C C Kartha. (2014)
Cardiovasc Diabetol.     13:38

ENPP1 121Q functional variant enhances susceptibility to coronary artery disease in South Indian patients with type 2 diabetes mellitus.

Sumi S*, Surya Ramachandran*, V Raman Kutty, Maulin M Patel, Anand TN, Ajit Mullassari, C C Kartha. (2017)
Molecular and Cellular Biochemistry     2017 435:67-72. (*equal first author)

Chapters in Book / Text

  • Books edited

    1. C.C. Kartha; Surya Ramachandran; Radhakrishna M. Pillai (1 August 2017). Mechanisms of Vascular Defects in Diabetes Mellitus. Springer. ISBN 978-3-319-60324-7.

    Chapters in book

    1. Surya Ramachandran, M Radhakrishna Pillai and C.C. Kartha. Monocyte Factors in Pathogenesis of Vascular Lesions in Diabetes. In Mechanisms of Vascular Defects in Diabetes Mellitus, Advances in Biochemistry in Health and Disease 17. Eds. Kartha CC, Ramachandran S, Pillai MR. Springer International Publishing. 2017; pp.141-158. DOI 10.1007/978-3-319-60324-7_15.

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