Direct DNA binding by BRCA1 on β-hCG promoter and its clinical implications

Neethu Krishnan , Neetha R L , Arathy V. Warrier , Induprabha Yadev , Jaimie Anandan , Sankar Sundaram , Arathi Rajan ,Prianka Kumari , Shreya Sara Ittycheria , Manasa V.G ,Serbin Mohammed , Preethamol S , Rakesh Sathish Nair , Priya Srinivas (2024)
Heliyon     Volume 10 Issue 17e37064 September 15 2024

Xenoestrogen and Its Interaction with Human Genes and Cellular Proteins: An In-Silico Study

Arathy V Warrier , Manasa Vg , Neetha R L , Neethu Krishnan , Prianka Kumari , Shreya Sara Ittycheria , Priya Srinivas (2024)
Asian Pacific Journal of Cancer Prevention (APJCP)     25(6):2077-2087 Doi: 10.31557/APJCP.2024.25.6.2077. IF : 2.514

βhCG mediates immune suppression through upregulation of CD11b+Gr1+ Myeloid Derived Suppressor Cells, CD206+M2 macrophages, and CD4+FOXP3+ regulatory T-cells in BRCA1 deficient breast cancers.

Geetu Rose Varghese, Dipyaman Patra, Vishnu Sunil Jaikumar, Arathi Rajan, Neetha R Latha, Priya Srinivas (2023)
Immunology     1-16; DOI: 10.1111/imm.13673 IF : 7.397

Modulation of BRCA1 mediated DNA damage repair by deregulated ER-α signaling in breast cancers

Arathi Rajan, Geetu R Varghese, Induprabha Yadev, Jaimie Anandan, Neetha R Latha, Dipyaman Patra, Neethu Krishnan, Krithiga Kuppusamy, Arathy V Warrier, Satej Bhushan, Revathy Nadhan, Ram Mohan Ram Kumar, Priya Srinivas (2022)
American Journal of Cancer Research     12(1):17-47

BRCA1 promoter hypermethylation in human placenta: A hidden link with β-hCG expression

Revathy Nadhan, Jayashree V V, Satheesh K S, Sreelatha K H, C Nirmala, Santha S, P V Aysha, Sreelekha Y, R S Krishnapriya, B V Amritha K, Sreevidya P S, Arathi R, Neetha R L, Geetu R V, Ratheeshkumar T, Sarada A, Dev S U Jithin, T V A Kumar, Priya Srinivas* (2020)
Carcinogenesis     41(5):611-624. doi:10.1093/carcin/bgz117 IF. 5.334

β-hCG-induced mutant BRCA1 ignites drug resistance in susceptible breast tissue.

Satheesh Kumar Sengodan, Sreelatha K Hemalatha, Revathy Nadhan, Thara Somanathan, Arun Peter Mathew, Arkadiusz Chil, Janusz Kopczynski, Rakesh Sathish Nair, Jerald Mahesh Kumar, Priya Srinivas* (2019)
Carcinogenesis     40(11):1415-1426. doi:10.1093/carcin/bgz070 IF. 5.334

BRCA1 Defective Breast Cancer Cells Induce in vitro Transformation of Cancer Associated Fibroblasts (CAFs) to Metastasis Associated Fibroblasts (MAF)

Sreelatha KH, Satheesh KS, Revathy N, Jithin Dev, Reshma R S, Veena S, Ratheeshkumar T, Arathi R, Neetha R L, Geetu R V, Arun Peter M, Thara S, and Priya Srinivas*. (2018)
Scientific Reports     8(1):13903. IF. 4.01

Proteomic profiling of β-hCG induced spheres in BRCA1 defective triple negative breast cancer cells.

Satheesh Kumar Sengodan, Arathi Rajan, Sreelatha Krishnakumar Hemalatha, Revathy Nadhan, Abdul Jaleel and Priya Srinivas*. (2018)
Journal of Proteome Research     17(1):276-289. doi:10.1021/acs.jproteome.7b00562 IF. 4,268

BRCA1 regulation on β-hCG: A mechanism for tumorigenicity in BRCA1 defective breast cancer.

Satheesh K S, Revathy N, Rakesh S N, Sreelatha K H, Veena S, Reshma R S, Arathi R, Neetha R L, Geetu R V, Ratheeshkumar T, Jerald M K, Arkadiusz C, Thapasimuthu V A, Priya Srinivas*(2017)
Oncogenesis,     Sep 4;6(9):e376. doi: 10.1038/oncsis.2017.75 IF. 5.021

Chapters in Book / Text

    1. Reshma R S, Revathy Nadhan and Priya Srinivas. Plumbagin and Prostate Cancer Therapy. In the book "Complementary and Alternative Medicines in Prostate Cancer: A Comprehensive Approach", ISBN 9781498729871 - CAT# K26099, by CRC Press, December 6, 2016.
    2. Satheesh Kumar S, Sreelatha K H,, Revathy Nadhan, and Priya Srinivas. Role of BRCA1 in Breast Cancer Metastasis. Charpter 1, In the book "Gynecologic Cancers - Basic Sciences, Clinical and Therapeutic Perspectives", ISBN 978-953-51-4278-2, InTech, Europe, March 2nd, 2016.
    3. Revathy Nadhan, Priya Srinivas, M Radhakrishna Pillai. RTKs in Pathobiology of Head and Neck Cancers. Advances in Cancer Research (Elsevier) - Receptor Tyrosine Kinases in Cancer Progression and Therapeutics. Under Communication

Abstracts / Presentations / Invited Lectures

Contact

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