Human Molecular Genetics with specific reference
- Microsatellite Genetics
- Ecological genetics
Indian population is divided into several endogamous groups consisting of 4635 different communities with hierarchical caste structure. The basis of reproductive isolation of these populations is also highly varied, comprising of geographic, religious, ethnic or occupational backgrounds.
The main concern of our research is to search for the extent of genetic variability in ethnic communities and also search for ethnically predisposed variants for the various diseases under study. The population biology approaches would contribute to the understanding of infectious diseases and design and evaluation of intervention for their treatment and prevention. This is done by DNA fingerprinting profiling, Immunogenetic profiling and pharmacogenetic profiling. Linkage mapping strategies are also being carried out to identify the predisposed allele in a diseased individual.
Presently diseases like Schizophrenia, Ankylosing spondylitis, Intracranial aneurysm and Cancer are being investigated. In return this would help us in the identification and characterization of population level processes and structures, which contribute to the emergence, and maintenance of disease. I get involved in various diseases because of my clinical collaborators' sincere involvement with their patients.