Research Programs

images/research.png

Understanding the role of Notch and Wnt signaling in neocortical and cerebellar development

images/research.png

Functional characterization of homeobox gene Tlx3 (Hox11L2) in cerebellar development and its link to Autistic spectral disorders (ASD)

images/research.png

Development of a cell therapy strategy to treat glaucoma using retinal ganglion cells (RGCs) generated from embryonic stem (ES) cells/ Umbilical Cord Blood (UCB) derived mesenchymal stem cells

Current Research Grants

  • 2020 2018

    Expression of Notch independent Hes-1 (NIHes-1) specifically in ES derived organoids representing developing neocortex: Understanding its functional significance.
    Department of Biotechnology [DBT]

  • 2020 2017

    Guiding retinal ganglion cell axons to brain visual centers: Is Pax6 the key molecule?
    Department of Science & Technology [DST]

Research Grants Completed

    1. Transcriptional regulation of Tlx3 by Pax6 and its role on excitatory neural fate specification in vitro and in vivo.
      Kerala State Council for Science, Technology and Environment [KSCSTE] 2014-2016

    2. Characterization of Notch independent Hes-1 mediated maintenance and fate specification of neural progenitors.
      Department of Biotechnology [DBT] 2013-2016

    3. Transcriptional regulation of Tlx3 (Hox11L2) by Notch signaling and its involvement in excitatory vs. inhibitory fate specification of neural progenitors.
      Department of Science & Technology [DST] 2013-2016

    4. Differentiation of UCB stem cells into lineage specific cell types for therapeutic applications.
      Department of Biotechnology [DBT] 2008-2011

    5. Isolation and characterization of human embryonic stem (ES) cell line.
      Kerala State Council for Science, Technology and Environment [KSCSTE] 2007-2009

    6. Development of a cell therapy strategy to treat glaucoma using retinal ganglion cells (RGCs) generated from embryonic stem (ES) cells.
      Department of Biotechnology [DBT] 2006-2009

    7. Transplantation of embryonic stem (ES) cells engineered to produce GABA into hippocampus of rats with temporal lobe epilepsy for possible control of seizures.
      Department of Science & Technology [DST] 2004-2008

Contact

Rajiv Gandhi Centre for Biotechnology (RGCB),
Thycaud Post, Poojappura,
Thiruvananthapuram - 695 014, Kerala, India
+91-471-2529400 | 2347975 | 2348753
+91-471-2348096
webmaster@rgcb.res.in

My Gov www.mygov.in Prime Ministers National Relife Fund India Gov www.india.gov.in Make In India www.makeinindia.gov.in Make In India www.iredibleindia.org Data gov in www.data.gov.in www.pib.gov.in

Last Updated on: August 08, 2020
CERT-In Certified Website