Profile

The main focus of the laboratory is understanding the role of inflammation in physiology (innate immune response) and pathophysiology (cancer). We are particularly interested in the roles of Sphingosine 1-phosphate (S1P) in inflammation and carcinogenesis. Another area of our interest is Immunometabolism in cancer. The major question is to understand the crosstalk between immune cells and the tumor microenvironment (TME) and how TME modulates the metabolic process within immune cells. We use different in vitro and in vivo (transgenic mouse models, xenograft models, orthotopic and PDX models) in our study.