Mechanistic effect of citrus flavonoids on pancreatic beta- cells under induced oxidative stress Pancreatic beta-cells are particularly vulnerable to apoptosis when compared to other tissues. This might be because of oxidative stress, islet amyloid, or endoplasmic reticulum stress which causes changes in enzyme activity, ion channel transport, receptor signal transduction, deregulated gene expression thereby disrupting normal beta cell function. Progressive beta cell failure is often manifested as accelerated beta cell loss leading to a reduced beta cell mass. Beta cells have a relatively low level of antioxidant enzymes such as superoxide dismutase, glutathione peroxidase and catalase. Protection of pancreatic beta cells from oxidative stress is an interesting therapeutic option. Amelioration of oxidative stress and repair of existing beta-cells with return to full function may normalize insulin secretion and blood glucose levels. We attempt to evaluate the mechanistic effect of citrus flavonoid, quercetin on pancreatic beta cells under induced oxidative stress.
Rajiv Gandhi Centre for Biotechnology (RGCB), Thycaud Post,
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