Lekshmi K. Edison, PhD
Post-doctoral Fellow (DBT)
Characterisation of reactivation-associated putative protein Rv2817c, a CRISPR-associated endonuclease Cas1, of Mycobacterium tuberculosis
A previous study in our lab revealed that Rv2817c protein (Cas1) is uniquely present in the early phase of reactivation of MTB from dormancy. Many other key proteins involved in genetic recombination and DNA repair are also present either in high levels or are uniquely expressed during this phase. Taken together, these observations suggest that genome editing might play a significant role during reactivation of dormant MTB. My interest is to understand the physiological relevance of Cas1 in MTB.