Research Programs

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Germline stem cell maintenance, division and differentiation in testis

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Factors regulating meiotic drive in testis

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Critical molecules regulating biomembrane structure and cell fusion during fertilization

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Cellular Deprogramming during fertilization

Research Grants Completed

    1. Isolation of germline stem cells from adult mouse testis and evaluation of their pluripotency
      Department of Biotechnology [DBT] 2010-2011

    2. Charcterization of testis-specific tyramine receptor like protein (TRLP)
      Kerala State Council for Science, Technology and Environment [KSCSTE] 2008-2011

    3. Cloning, expression and functional characterization of a cyclin-like protein (CLP-1) from human germ cells
      Department of Science and Technology [DST] 2008-2011

    4. Sperm proteome profiling in human male infertility
      Department of Biotechnology [DBT]-National Bioscience Award Project 2007-2010

    5. Cloning, expression and semiquantitative analysis of protocadherins in human germ cells
      Council of Scientific and Industrial Research [CSIR] 2006-2009

    6. Characterization of RAFTS and RAFT-associated proteins of spermatozoa during capacitation and acrosome reaction
      Department of Biotechnology [DBT] 2006-2009

    7. Evaluation of the expression of a sterility locus gene TCTEX-1 and its relation with protein trafficking in spermatozoa from infertile and fertile human males
      Board of Research in Nuclear Sciences [BRNS] 2006-2009

    8. Mechanism of activation of NADPH Oxidase in blue-light signal transduction reactions in the coleoptile tip
      Department of Science and Technology [DST] 2004-2008

    9. Identification of superoxide generating machinery in mammalian spermatozoa
      Department of Science and Technology [DST] 2003-2007

    10. Charactrization of 54 kilodalton uterine protein and its involvement in early pregnancy
      University Grants Commission [UGC] 2002-2005

    11. Characterization of A/V CAM from human spermatozoa and its involvement in normal human fertility
      Department of Biotechnology [DBT] 2000-2004

    12. Biophysical and immunological aspects of the perturbations in post-vasectomy spermatozoa and its relation in irreversibility of fertility
      Council of Scientific and Industrial Research [CSIR] 1996-2000

    13. Isolation, purification and characterization of a transiently appearing endometrial adhesion molecule (EAM) in the mouse
      Department Of Atomic Energy [DAE] 1992-1995

    14. Active oxygen intermediates in female reproduction and the physico-chemical aspects of membrane configuration as a consequence of oxidative mechanisms at implantation
      Department of Science and Technology [DST] 1992-1995

    15. Free radical modulation of the physico-chemical architecture of mammalian sperm membranes and the molecular aspects of sperm-zona pellucida interaction
      Department of Science and Technology [DST] 1992-1995

    16. Studies on the isolation, purification and structural and functional characterization of Fc receptors from mammalian sperm
      Council of Scientific and Industrial Research [CSIR] 1990-1992

    17. Insect pest management through secondary plant metabolites: control of forest pest and mosquitoes
      M.P Council of Science and Technology 1988-1991

    1. Sponsored Grants

    2. Role of CLP-1 in cell cycle regulation in spermatogenic cells
      Department of Science and Technology [DST] 2013-2016

    3. Evaluation of cellular aging and genome stability in spermatogonial stem cells
      Council of Scientific and Industrial Research [CSIR] 2013-2016

    4. Association between stemness and TCTEX1 expression in testicular germ cells from adult mouse
      Board of Research in Nuclear Sciences [BRNS] 2011-2014

    5. Structural and phosphoproteome analysis of mouse sperm membrane rafts during their interaction with zona pellucida protein
      Department of Biotechnology [DBT] 2011-2014

Contact

Rajiv Gandhi Centre for Biotechnology (RGCB),
Thycaud Post, Poojappura,
Thiruvananthapuram - 695 014, Kerala, India
+91-471-2529400 | 2347975 | 2348753
+91-471-2348096
webmaster@rgcb.res.in