Profile

Research

Publications

Team

Alumni

G.S. Vinod Kumar, PhD

Scientist E-II

+91-471-2781217

gsvinod@rgcb.res.in

vinod kumargs
vinod kumargs

G.S. Vinod Kumar, PhD

Scientist E-I

+91-471-2781217

gsvinod@rgcb.res.in

  • Profile

    • PhD Polymer Chemistry – 2000 (Mahatma Gandhi University, Kottayam, India)
    • 2016 - till date : Scientist E II, Rajiv Gandhi Centre for Biotechnology
    • 2012-2016 : Scientist E I, Rajiv Gandhi Centre for Biotechnology
    • 2007- 2012: Scientist C, Rajiv Gandhi Centre for Biotechnology
    • 2004- 2007: Scientist B, Rajiv Gandhi Centre for Biotechnology
    • 2001: Research Associate, CSIR, Rajiv Gandhi Centre for Biotechnology
    • 2000: Senior Research Fellow, CSIR, Rajiv Gandhi Centre for Biotechnology
    • 2001: Post Doctoral Fellowship, Department of Biotechnology (DBT), Govt. of India
    • 2001 April: Research Associateship, Council for Scientific and Industrial Research (CSIR), Govt. of India

    Journals

    • Cancer Research
    • International Journal of Pharmaceutics
    • Journal of Controlled Release
    • Molecular Pharmaceutics
    • ACS Applied Materials & Interfaces
    • Resin developed for Solid Phase Peptide Synthesis, US Patent: US 7,135,534 B2
    • A new flexible mechanically stable polymer support for solid phase peptide synthesis
      Indian patent : 248550
    • A method for synthesis of dendrimer polymeric resins for solid phase peptide synthesis
      Indian patent : 248244
  • Research

    Our laboratory mainly focus in three major areas

    1. Nanoparticle based controlled drug delivery
    2. Tissue Engineering
    3. Solid phase peptide synthesis.

    Controlled Drug Release Systems

    Polymer nanoparticle and film based drug releasing systems

    In Cancer

    The application of biodegradable polymeric particles in the scale of nanometers as a controlled release dosage form of anticancer drugs has generated immense interest among researchers. Nanoparticle can improve the bioavailability of poorly absorbed drugs and nanoparticles are able to penetrate cells for cellular internalization, it can penetrate connective tissues, hence the drug delivery can be efficiently done to the targeted tissues without clogging capillaries. The ability of nanoparticles to improve drug diffusion through biological barriers is a typical benefit for the delivery of anticancer agents. We have synthesized different biodegrading polymeric nanoparticles of Polyester family like PLA, PGA and PLGA based and other fast degrading systems with anticancer drugs using surface ligands for active targeting. We have also synthesized drug loaded polymer films and in the present area we focus to create new polymer based implanting systems in drug releasing applications for different type of cancers.

    Development of degradable scaffolds for cell differentiation

    Many attempts have been made to engineer, small caliber arterial substitutes involving synthetic polymeric materials coupled with biological modification to improve biocompatibility. Occurrence of thrombosis is still a main problem encountered in small diameter blood vessel reconstruction with polymeric materials. Many polylactic or polyglycolide based scaffolds employed, fails to achieve the necessary compliance like cell adhesion, proliferation and growth factor release. Development of matrices with all these properties is still a challenge. Effort to enhance the functional property of these systems, we are looking in the present project a possible designing of a novel vascular graft of multilayer cell seeding on a new polymer. The study aims at preparing three dimensional spongy hybrid carrier scaffolds for multipurpose vascular application: requiring Vascular Smooth Muscle Cell [VSMC] adhesion, proliferation, and growth factor signaling on one side as a layer on carrier scaffold, and Endothelial Cell [EC] on other layer of the carrier scaffold using suitable porogen.

    Engineering of scaffolds that promote tissue regeneration by incorporating cell signaling elements such as growth factors and wound healing peptides alters the wound environment enabling accelerated regeneration. In this study we aim to fabricate a biomedical system using polymers incorporating growth factors and wound healing peptides for accelerated wound healing and tissue regeneration. Structural and physiochemical characterization studies will be used for evaluating the system. The fabricated system will be characterized further by using suitable in vitro and in vivo models.

    Solid phase peptide synthesis

    Since Merrifield's original report over three decades ago describing solid phase synthesis of a simple tetra peptide on low crosslinked polystyrene beads, the approach has been improved and generalized to the synthesis of complicated peptides, long oligonucleotides and myriad of small organic molecules. The success of such efforts is often affected by choice of polymeric support, with regard to mechanical stability, swellability and compatibility with a range of hydrophilic/ hydrophobic solvents. The present area focuses to synthesis novel polymer supports for solid phase peptide and its application in controlled drug delivery, wound healing and in tissue engineering for the creation of new generation scaffold for biomedical applications.

    PhD Awarded

    1. Lekha Nair K awarded her PhD degree in 2013 and received the Dr. M R Das career award for best outgoing PhD student
    2. Siyad M A awarded his PhD degree in 2013

    ONGOING AND COMPLETED FUNDED EXTRA-MURAL RESEARCH GRANTS

    As Principal Investigator

    1. A Novel Site Specifically Targeting Nanoparticle Based Oral – Drug And SiRNA Releasing Polymer Systems For Colon Cancer.
      (Department of Biotechnology, 2010-13) (1. 22 Crore)
    2. Novel polymer nanoparticles based drug releasing systems for improving the efficacy of drug administration in cancer chemotherapy.
      (Department of Biotechnology, 2008-12) (42 Lacks)
    3. Development of a new three dimensional microporous spongy hybrid scaffold for seeding vascular cells.
      (Department of Biotechnology, 2008-11) (33 Lacks)
    4. Development of Novel Biodegradable Drug Releasing Polymer Systems for Cancer Therapy.
      (Department of Biotechnology, 2007-10) (15 Lacks)

    Awards and Honours

    1. Siyad M A was awarded first prize for the poster presentation at Kerala Science Congress held at Technopark, Thiruvananthapuram, on January, 2013
    2. Ashwani Kumar N was awarded Best paper award for the oral presentation at National Seminar on Emerging Trends in Chemical Science, St Aloysius College Mangalore; Feb 14-16, 2013
    3. Ashwani Kumar N was awarded second prize for the poster presentation at International Conference on Recent Advances in Material Science and Technology (ICRAMST-13). National Institute for Technology Surathkal Karnataka; Jan 17-19, 2013
  • Publications

    1. Mrunal Vitthal Wanjale & Kumar GSV. Peptides as a therapeutic avenue for nanocarrier-aided targeting of glioma. Expert Opinion on Drug Delivery  2017; 14,811-824.
    2. N. Ashwanikumar, Nisha Asok Kumar, P.S. Saneesh Babu, K.C. Sivakumar, Mithun Varghese Vadakkan, Parvathi Nair, I. Hema Saranya, S. Asha Nair, Kumar GSV.* Self-assembling peptide nanofibers containing phenylalanine for the controlled release of 5-fluorouracil. International Journal of Nanomedicine 2016; 11:5583-5594.
    3. Mithun Varghese Vadakkan and Kumar GSV. Advancements in devices and particle engineering in dry powder inhalation technology. Current Topics in Medicinal Chemistry 2016; 16:1990-2008.
    4. Mithun Varghese Vadakkan, S.S. Binil Raj, Chandrasekharan C. Kartha and Kumar GSV.* Cationic, amphiphilic dextran nanomicellar clusters as an excipient for dry powder inhaler formulation. Acta Biomaterialia  2015 ; 23:172-188.
    5. Mithun Varghese Vadakkan and Kumar GSV.* Cryo-crystallization under a partial anti-solvent environment as a facile technology for dry powder inhalation development. RSC Advances 2015 ; 5:73020.
    6. M.A.Siyad and Kumar GSV.* Synthesis and characterization of linear and cyclic endothelin peptides on PEGylated poly(O-benzyl ether) dendrimeric supports. Polymer  2015 ; 67:80-91.
    7. Jisha J. Pillai, Arun Kumar T. Thulasidasan, Ruby John Anto, Devika C Nandan, N. Ashwanikumar and Kumar GSV.* Curcumin entrapped folic acid conjugated PLGA–PEG nanoparticles exhibit enhanced anticancer activity by site specific delivery. RSC Advances  2015 : 5,25518-25524.
    8. N. Ashwani Kumar, Nisha Asok Kumar, S. Asha Nair and Kumar GSV.* Dual drug delivery of 5-fluorouracil (5-FU) and methotrexate (MTX) through random copolymeric nanomicelles of PLGA and polyethylenimine demonstrating enhanced cell uptake and cytotoxicity. Colloids and Surfaces B: Biointerfaces 2014; 122:520 - 528.
    9. N. Ashwani Kumar, Nisha Asok Kumar, S. Asha Nair and Kumar GSV.* 5-Fluorouracil-lipid conjugate: Potential candidate for drug delivery through encapsulation in hydrophobic polyester-based nanoparticles. Acta Biomaterialia 2014; 10:4685-4694.
    10. N. Ashwanikumar, Nisha Asok Kumar, S. Asha Nair and Kumar GSV.* Phenylalanine-containing self-assembling peptide nanofibrous hydrogel for the controlled release of 5-fluorouracil and leucovorin. RSC Advances 2014; 4:29157-29164.
    11. Jisha Jayadevan Pillai, Arun Kumar Theralikattu Thulasidasan, Ruby John Anto, Devika Nandan Chithralekha, Ashwanikumar Narayanan and Kumar GSV.* Folic acid conjugated cross-linked acrylic polymer (FA-CLAP) hydrogel for site specific delivery of hydrophobic drugs to cancer cells. Journal of Nanobiotechnology 2014; 12:25.
    12. M. A. Siyad and Kumar GSV.* A class of linker free amphiphilic PEG grafted polymer support for linear and cyclic peptides. RSC Advances 2014; 4:60404-60408.
    13. Lekha Nair K, Sankar Jagadeeshan, S Asha Nair and Kumar GSV.* Folic acid conjugated d-valerolactone-poly(ethyleneglycol) based triblock copolymer as a promising carrier for targeted doxorubicin delivery. PLOS ONE 2013;8 (8) e70697.
    14. Siyad MA and Kumar GSV.* Synthetic evaluation of disulphide-bonded sarafotoxin on a poly(oxy ether) grafted dendrimeric poly(alkylamine) support for polymer assisted organic synthesis. Organic & Biomolecular Chemistry 2013; 11:4860-4870.
    15. Mithun Varghese Vadakkan, K Annapoorna, KC Sivakumar, Sathish Mundayoor and Kumar GSV.* Dry powder cationic lipopolymeric nanomicelle inhalation for targeted delivery of antitubercular drug to alveolar macrophage. International Journal of Nanomedicine 2013; 8:2871-2885.
    16. Siyad MA and Kumar GSV.* PEGylated dendrimer polystyrene support: synthesis, characterisation and evaluation of biologically active peptides. Amino Acids 2013;44(3) :947-959.
    17. Siyad MA and Kumar GSV.* Synthesis, Characterization, and Application of Bisphenol A Glycerolate Dimethacrylate Cross-Linked Polystyrene (PS-BGD): A Novel Support for Gel Phase Peptide Synthesis. Current Organic Synthesis 2013;10 (2): 318-327.
    18. Deepa G, Ashwanikumar N, Pillai JJ and Kumar GSV.* Polymer nanoparticles-a novel strategy for administration of Paclitaxel in cancer chemotherapy. Current Medicinal Chemistry 2012; 19(36):6207-6213.
    19. Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ and Kumar GSV.* Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy. International Journal of Nanomedicine 2012;7 :4077-4088.
    20. Ashwanikumar N, Kumar NA, Nair SA and Kumar GSV.* Methacrylic-based nanogels for the pH-sensitive delivery of 5-fluorouracil in the colon. International Journal of Nanomedicine 2012;7 :5769-5779.
    21. Siyad MA and Kumar GSV.* Synthesis, characterization, and evaluation of PS-PPDC resin: a novel flexible cross-linked polymeric support for solid-phase organic synthesis. Biopolymer: Peptide Sciences 2012;98(3) :239-248.
    22. Simon AM, Jagadeeshan S, Abraham E, Akhilandeshwaran A, Pillai JJ, Kumar NA, Sivakumari AN and Kumar GSV.* Poly (D,L-lactic-co-glycolide) nanoparticles for the improved therapeutic efficacy of all-trans-retinoic acid: a study of acute myeloid leukemia (AML) cell differentiation in vitro. Medicinal Chemistry 2012;8(5) :805-810.
    23. Nair KL, Thulasidasan AK, Deepa G, Anto RJ and Kumar GSV.* Purely aqueous PLGA nanoparticulate formulations of curcumin exhibit enhanced anticancer activity with dependence on the combination of the carrier. International Journal of Pharmaceutics 2012;425(1-2): 44-52.
    24. Siyad MA and Kumar GSV.* SPED-(styrene-polyethyleneglycol diacrylate-9-decen-1-ol): a novel resin for solid phase peptide synthesis; synthesis and characterization of biologically potent endothelin classes of peptides. Combinatorial Chemistry & High Throughput Screening 2012;15(5): 386-394.
    25. Nair KL, Vidyanand S, James J and Kumar GSV.* Pilocarpine-loaded poly(DL-lactic-co-glycolic acid) nanoparticles as potential candidates for controlled drug delivery with enhanced ocular pharmacological response. Journal of Applied Polymer Sciences 2012;124(3): 2030-2036.
    26. Siyad MA and Kumar GSV.* Poly(ethylene glycol) grafted polystyrene dendrimer resins: Novel class of supports for solid phase peptide synthesis. Polymer 2012;53: 4076-4090.
    27. K Lekha Nair, Sankar Jagadeeshan, S Asha Nair and Kumar GSV.* Evaluation of triblock copolymeric micelles of delta- Valerolactone and poly (ethylene glycol) as a competent vector for doxorubicin delivery against cancer. Journal of Nanobiotechnology 2011; 9:42.
    28. K Lekha Nair, Sankar Jagadeeshan, S Asha Nair and Kumar GSV.* Biological evaluation of 5-fluorouracil nanoparticles for cancer chemotherapy and its dependence on the carrier, PLGA. International Journal of Nanomedicine 2011; 6:1685-1697.
    29. M.A. Siyad, Arun S.V. Nair and Kumar GSV.* Solid-Phase Peptide Synthesis of Endothelin Receptor Antagonists on Novel Flexible, Styrene-Acryloyloxyhydroxypropyl Methacrylate-Tripropyleneglycol Diacrylate [SAT] Resin. Journal of Combinatorial Chemistry 2010; 12:298-305.
    30. Kumar GSV and K. Santhosh Kumar. Immobilization of catalase on a Novel PolymerSupport, CLPSER: Role of the Macromolecular Matrix on Enzyme Activity. Journal of Applied Polymer Science 2005; 97:8-19.
    31. Kumar GSV, S.Leena and K. Santhosh Kumar. Synthesis of a shark repellent peptide toxin, Pardaxin (16-33) on a highly flexible polymer support: CLPSER. Protein and Peptide Letters 2004; 6: 547-554.
    32. Kumar GSV and Beena Mathew. Effect of nature and degree of crosslinking on the catalase-like activity of polystyrene-supported Schiff base metal complexes. Journal of Applied Polymer Science 2004; 92:1271-1278.
    33. Kumar GSV and Beena Mathew. Influence of the nature of crosslinking agents on the catalase-like activity of polystyrene-supported Schiff base metal complexes. Journal of Macromolecular Sciences Pure and Applied Chemistry 2004;41(9): 1037-1050.
    34. Kumar GSV and Beena Mathew. Polymer-metal complexes of glycine functions supported on N, N’-methylene-bis-acrylamide (NNMBA)-crosslinked polyacrylamides: Synthesis, characterization and catalytic activity. European Polymer Journal 1998; 34 (8): 1185.
    1. Ashwani Kumar.N, Nisha Asok Kumar, K.C.Sivakumar, Asha.S.Nair and GS Vinod Kumar. Self assembling peptide nanofibrous scaffold for the controlled delivery of 5-Fluorouracil. 6th International meeting on Halogen Chemistry (HALCHEM-6).Indian Institute of Science, Bangalore; 2012.
    2. Mithun V. Varghese, Annapoorna K, Sivakumar K C, Satish Mundayoor and G S Vinod Kumar. "Cationic lipopolymer micelle as an efficient carrier for delivery of xenobiotics to human macrophage cells." INDO-US symposium on structure dynamics and mechanics of biological membranes-2012. Department of Chemical Engineering, Indian Institute of Science, Bangalore. 2012.
    3. Ashwani Kumar.N, Nisha Asok Kumar, Asha.S.Nair and GS Vinod Kumar. Facile synthesis and biological evaluation of a polymeric nanogel for the pH responsive delivery of 5-Fluorouracil, National Seminar on Emerging Trends in Chemical Science, St Aloysius College Mangalore; 2013.
    4. Ashwani Kumar.N, Nisha Asok Kumar, K.C.Sivakumar, Asha.S.Nair and GS Vinod Kumar. Peptide based nanomaterials:-A promising tool for the controlled delivery of 5-Fluorouracil. International Conference on Recent Advances in Material Science and Technology (ICRAMST-13). National Institute for Technology Surathkal Karnataka; 2013.
    5. Ashwani Kumar.N, Nisha Asok Kumar, Asha.S.Nair and GS Vinod Kumar. A novel pH responsive polymeric drug delivery system for colon cancer. 25th Kerala Science Congress. Techno Park, Trivandrum; 2013.
    6. Ashwani Kumar.N, Nisha Asok Kumar, K.C.Sivakumar, Asha.S.Nair and GS Vinod Kumar. Peptide based nanomaterials:-A promising tool for the controlled delivery of 5-Fluorouracil 5th International Conference on Current Trends in Drug Discovery and Research (CTDDR-2013).Central Drug research Institute, Lucknow; 2013.
    7. Mithun V. Varghese, Annapoorna K, Sivakumar K C, Satish Mundayoor and G S Vinod Kumar. "Dry powder inhaler formulation of an anti TB drug for treating pulmonary tuberculosis." 25th Kerala science congress-2013. Technopark, Thiruvanathapuram. 2013.
    8. Mithun V Varghese, Annapoorna K, Sivakumar K C, Satish Mundayoor and G S Vinod Kumar. "Development of cationic amphiphilic lipopolymer as an efficient carrier for anti-TB dry powder inhalation formulation." Current Trend in Drug Discovery Research (CTDDR) – 2013, Central drug research institute, Lucknow. 2013.
  • Team


    Amritha Vijayan, PhD Student [UGC-SRF Fellow]

    Wound healing is a process in which injured skin repairs itself. Most skin wounds can heal naturally, but when extensive or irreversible damages are caused, it is necessary to use skin substitutes to aid in their repair and regeneration. Engineering of scaffolds that promote tissue regeneration by incorporating cell signaling elements such as growth factors and wound healing peptides alters the wound environment enabling accelerated regeneration. In this study we aim to fabricate a biomedical system using polymers incorporating growth factors and wound healing peptides for accelerated wound healing and tissue regeneration. Structural and physiochemical characterization studies will be used for evaluating the system. The fabricated system will be characterized further by using suitable in vitro and in vivo models.

    Amritha Vijayan
    Amritha Vijayan

    Amritha Vijayan, PhD Student [UGC-SRF Fellow]

    Wound healing is a process in which injured skin repairs itself. Most skin wounds can heal naturally, but when extensive or irreversible damages are caused, it is necessary to use skin substitutes to aid in their repair and regeneration. Engineering of scaffolds that promote tissue regeneration by incorporating cell signaling elements such as growth factors and wound healing peptides alters the wound environment enabling accelerated regeneration. In this study we aim to fabricate a biomedical system using polymers incorporating growth factors and wound healing peptides for accelerated wound healing and tissue regeneration. Structural and physiochemical characterization studies will be used for evaluating the system. The fabricated system will be characterized further by using suitable in vitro and in vivo models.

    Meenu vasudevan S, PhD Student [DST INSPIRE-SRF Fellow]

    The treatment of brain diseases is limited by the inadequacy in delivering therapeutic agents in such a way that drug molecules reach the desired targets. In order to achieve efficient treatments, it is necessary to transport therapeutic agents across the specialized vascular system of the brain, the Blood Brain Barrier (BBB), which can present formidable challenges. The conventional drug delivery systems increase the concentration of the drug in the systemic circulation but may not lead to a proportional increase in the concentration of drug in the central nervous system (CNS). Aim of the work is to develop suitable drug delivery systems using biodegradable polymers especially for the treatment of brain tumors. Targeted delivery can be achieved by using appropriate ligands. The systems will be characterized, optimized and biological evaluation done in suitable in vitro and in vivo models.

    Meenu Vasudevan. S
    Meenu Vasudevan. S

    Meenu vasudevan S, PhD Student [DST INSPIRE-SRF Fellow]

    The treatment of brain diseases is limited by the inadequacy in delivering therapeutic agents in such a way that drug molecules reach the desired targets. In order to achieve efficient treatments, it is necessary to transport therapeutic agents across the specialized vascular system of the brain, the Blood Brain Barrier (BBB), which can present formidable challenges. The conventional drug delivery systems increase the concentration of the drug in the systemic circulation but may not lead to a proportional increase in the concentration of drug in the central nervous system (CNS). Aim of the work is to develop suitable drug delivery systems using biodegradable polymers especially for the treatment of brain tumors. Targeted delivery can be achieved by using appropriate ligands. The systems will be characterized, optimized and biological evaluation done in suitable in vitro and in vivo models.

    Mrunal Wanjale, PhD Student [DST INSPIRE-SRF Fellow]

    I am working in the area of developing novel drug releasing implant system for treatment of Glioma. Gliomas are the most common anaplastic tumors that are observed in children, adults as well as elderly people. The cornerstone of the management of these tumors has been surgery, followed by post operative radiotherapy and concurrent treatment with various alkylating agents; but their use is limited because of insufficient delivery across the blood brain barrier (BBB). Here we wish to address this problem, by designing biodegradable implant systems for sustained release of therapeutic agents for brain tumour as a regional chemotherapy technique.

    Mrunal Wanjale, PhD Student [DST INSPIRE-SRF Fellow]

    I am working in the area of developing novel drug releasing implant system for treatment of Glioma. Gliomas are the most common anaplastic tumors that are observed in children, adults as well as elderly people. The cornerstone of the management of these tumors has been surgery, followed by post operative radiotherapy and concurrent treatment with various alkylating agents; but their use is limited because of insufficient delivery across the blood brain barrier (BBB). Here we wish to address this problem, by designing biodegradable implant systems for sustained release of therapeutic agents for brain tumour as a regional chemotherapy technique.

    Teena Jacob Chirayil, PhD Student [CSIR-SRF Fellow]

    Liver cancer is the fifth most prevalent cancer in the world. My work focuses to treat Hepatocellular Carcinoma that originate primarily in the liver by the aid of nanoparticle based drug-delivery systems whose surface is tailored with specific targeting ligands for the receptors over expressed in Liver cancer cells with suitable animal models.

    Teena Jacob Chirayil, PhD Student [CSIR-SRF Fellow]

    Liver cancer is the fifth most prevalent cancer in the world. My work focuses to treat Hepatocellular Carcinoma that originate primarily in the liver by the aid of nanoparticle based drug-delivery systems whose surface is tailored with specific targeting ligands for the receptors over expressed in Liver cancer cells with suitable animal models.

    Akhil K Mohan , PhD Student [UGC-JRF Fellow]

    My work is developing tumor specific targeted novel nanocarriers for the efficient delivery of siRNA and anticancer agent together to breast tumors. Specific knock down of target gene expression is mediated by siRNA. This involves DICER and the RISC, causing degradation of the cognate mRNA and preventing the corresponding protein expression. Chemotherapy is one of the most common cancer treatments in clinics. In most cases, the clinical responses show that the efficacy of chemotherapy is limited by the development of multi drug resistance. This can be addressed by combination therapy, in which we are creating a novel nano drug delivery system that can efficiently release both the drug and siRNA to tumor cells.

    Akhil K Mohan , PhD Student [UGC-JRF Fellow]

    My work is developing tumor specific targeted novel nanocarriers for the efficient delivery of siRNA and anticancer agent together to breast tumors. Specific knock down of target gene expression is mediated by siRNA. This involves DICER and the RISC, causing degradation of the cognate mRNA and preventing the corresponding protein expression. Chemotherapy is one of the most common cancer treatments in clinics. In most cases, the clinical responses show that the efficacy of chemotherapy is limited by the development of multi drug resistance. This can be addressed by combination therapy, in which we are creating a novel nano drug delivery system that can efficiently release both the drug and siRNA to tumor cells.

    Nanditha CK , PhD Student [UGC-JRF Fellow]

    Wound healing is a complex process that requires coordination between different cell types and an appropriate extracellular microenvironment. Chronic wounds cause major problems in the healing process due to persistent infection, excess inflammation etc. While there has been extensive investigation to find new methods to improve cutaneous wound care, the management of chronic wounds, burns, and skin wound infection remain challenging clinical problems even today. Fabrication of biomaterials along with wound healing peptides having the ability to fight infections along with accelerated regeneration potential will be the main aim of my study.

    Nanditha CK , PhD Student [UGC-JRF Fellow]

    Wound healing is a complex process that requires coordination between different cell types and an appropriate extracellular microenvironment. Chronic wounds cause major problems in the healing process due to persistent infection, excess inflammation etc. While there has been extensive investigation to find new methods to improve cutaneous wound care, the management of chronic wounds, burns, and skin wound infection remain challenging clinical problems even today. Fabrication of biomaterials along with wound healing peptides having the ability to fight infections along with accelerated regeneration potential will be the main aim of my study.

  • Alumni