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| >The main focus of our lab is towards understanding the signaling crosstalks involved in maintenance/proliferation of neural stem cells and their fate specific differentiation. The long term goal is to develop cell replacement therapies to treat refractory temporal lobe epilepsy and Glaucoma. Recently our group has identified a novel Notch independent Hes-1 activation pathway in a subset of neural progenitors which is critical in its maintenance and proliferation (Sanalkumar et. al., J. Neurochem; 2010: DOI:10.1111/j.1471-4159.2010.06574.x). |
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In addition to these our group is also involved in characterizing the factors regulating the excitatory Vs inhibitory fate of differentiating neurons, neural fate specific differentiation of Umbilical Cord Blood derived mesenchymal stem cells, identification of specific markers for retinal ganglion cells (RGCs) and development of biodegradable scaffolds for transplantation studies |
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