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R. V. Omkumar, Ph.D.
Scientist F
Tel : +91-471-2529483
Email : omkumar@rgcb.res.in

 

Peer reviewed

Peer reviewed

  1. Cheriyan J, Kumar P, Mayadevi M, Surolia A, Omkumar R. V. (2011) Calcium/Calmodulin Dependent Protein Kinase II Bound to NMDA Receptor 2B Subunit Exhibits Increased ATP Affinity and Attenuated Dephosphorylation. PLoS ONE 6(3): e16495. doi:10.1371/journal.pone.0016495
  2. Biju V., Mundayoor S., Omkumar R. V., Anas A., and Ishikawa M. (2009) Bioconjugated quantum dots for cancer research: Present status, prospects and remaining issues. Biotechnol. Adv. 2009 Dec 5. [Epub ahead of print] http://www.sciencedirect.com/scidirimg/clear.gifdoi:10.1016/j.biotechadv.2009.11.007
  3. Muhammed M. A., Verma P. K., Pal S. K., Kumar R. C., Paul S., Omkumar R. V., and Pradeep T. (2009) Bright, NIR-emitting Au23 from Au25: characterization and applications including biolabeling. Chemistry 15, p10110-20.
  4. Rajeevkumar, R., Suma Priya, S., Mayadevi, M., Mathew Steephan, Santhoshkumar, T. R., John Cheriyan, Sanalkumar, R., Pradeep, K. K., Jackson James, and Omkumar R. V. (2009) Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with Calcium/calmodulin dependent protein kinase II. J. Neurochem., 110, p 92-105.
  5. Pradeep K. K., John Cheriyan, Suma Priya, S., Rajeevkumar, R., Mayadevi, M., Praseeda, M., and Omkumar R. V. (2009) Modulation of catalysis of CaMKII by NMDA receptor subunit 2B. Biochem. J., 419, p123-32.
  6. Anshup J., Sai Venkataraman, Chandramouli Subramaniam, R. Rajeev Kumar, Suma Priya, T. R. Santhosh Kumar, R. V. Omkumar, Annie John and T. Pradeep (2005) Growth of Gold Nanoparticles in Human Cells. Langmuir 21, p 11562-7
  7. M. Praseeda, K. K. Pradeep, A. Krupa, S. Sri Krishna, S. Leena, R. Rajeev Kumar, John Cheriyan, M. Mayadevi, N. Srinivasan, and R. V. Omkumar (2004) Influence of a mutation in the ATP–binding domain of Calcium/Calmodulin dependent protein kinase II on its interaction with peptide substrates. Biochem. J. 378, p 391-397
  8. Praseeda M., Beena Mary K, Asha Sarah John, and Omkumar R. V. (2004) The C-terminus of CaMKII is truncated when expressed in E.coli. Protein Pept. Lett. 11, p 175-179
  9. Praseeda M, Mayadevi M., and Omkumar R. V. (2004) Interaction of Peptide substrate outside the active site influences catalysis by CaMKII. Biochem.Biophys.Res.Commun. 313, p 845-849
  10. Seetha K., Banerjee N. S., Omkumar R. V. and Purushothama M. G. (2004) Cloning and Characterization of Partial Promoter of HMGCoA Reductase from Andrographis paniculata (Burm.f.) Wall.ex Nees - A Tropical medicinal Plant. J. Plant Biochem. Biotech. 14, p 41-44
  11. Mayadevi M., Praseeda M., Kumar K. S., and Omkumar R. V. (2002) Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII. Biochem. Biophys. Acta. 1598, p 40-45.
  12. Omkumar R. V., Kiely M. J., Rosenstein A. J., Min K-T, and Kennedy M. B. (1996) Identification of a Phosphorylation Site for Calcium/Calmodulin-dependent Protein Kinase II in the NR2B Subunit of the N-Methyl-D-aspartate Receptor. J. Biol. Chem. 271, p 31670 - 31678
  13. Omkumar R. V. and Rodwell V. W. (1994) Phosphorylation of Ser871 Impairs the Function of His865 of Syrian Hamster 3-Hydroxy-3-methylglutaryl-CoA Reductase. J. Biol. Chem. 269, p 16862 - 16866
  14. Omkumar R. V., Darnay B. G. and Rodwell V. W. (1994) Modulation of Syrian Hamster 3-Hydroxy-3-methylglutaryl-CoA Reductase Activity by Phosphorylation. Role of Serine 871. J. Biol. Chem. 269 , p 6810 - 6814
  15. Omkumar R. V., Kadam S. M., Banerji A., and Ramasarma T. (1993) On the Involvement of Intramolecular Protein Disulfide in the Irreversible Inactivation of 3-Hydroxy-3-methylglutaryl-CoA Reductase by Diallyl Disulfide. Biochim. Biophys. Acta 1164, p 108-112
  16. Omkumar R. V., and Ramasarma T. (1993) Irreversible Inactivation of 3-Hydroxy-3-methylglutaryl-CoA Reductase by H2O2. Biochim. Biophys. Acta 1156, p 267-274
  17. Omkumar R. V., Gaikwad A. S., and Ramasarma T. (1992) Feedback-type Inhibition of Activity of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase by Ubiquinone. Biochim. Biophys. Res. Commun. 184, p 1280-1287
  18. Omkumar R. V., Mehta P. P., Ramakrishna Kurup C. K., and Ramasarma T. (1992) Preparation of a Soluble 58 kDa-3-hydroxy-3-methylglutaryl CoA Reductase from Liver Microsomes and its Inhibition by Ethoxysilatrane, a Hypocholesterolemic Compound. Mol. Cell. Biochem. 110, p 145-153
  19. Omkumar R. V., Banerji A., Kurup, C. K. R., and Ramasarma T. (1991) The Nature of Inhibition of 3-Hydroxy-3-methylglutaryl CoA Reductase by Garlic-derived Diallyl Disulfide. Biochim. Biophys. Acta 1078, p 219-225
  20. Ushadevi S., Omkumar R. V., and Ramasarma T. (1988) Studies on the Distribution and Changes in Concentration of Iron and Iron-dependent Inhibitor Protein of Hydroxymethyl glutaryl CoA Reductase. Indian J. Biochem. Biophys. 25, p 664-673
Important Conference Presentations
  1. The interaction of Calcium/calmodulin dependent protein kinase II with NR2B subunit of NMDA receptor-Effects on catalysis. Pradeep, K. K., Mayadevi, M., Praseeda, M., and Omkumar R V Poster presentation by Pradeep, K. K. at the Cold Spring Harbor Symposium on “Channels, Receptors and Synapses”, April 21-April 25, 2004, at Cold Spring Harbor Laboratory, USA
  2. A System for studying intracellular binding between CaMKII and NMDA-receptor subunits. Rajeev Kumar, R., and Omkumar R V Poster presentation by Rajeev Kumar, R. at the XXVII All India Cell Biology Conference & International Symposium on Frontiers in Biomedical Research & Technologies, January 7-January 10, 2004, at University of Pune, INDIA This won the Dr. Manasi Ram Memorial Award for the Best Poster Presentation
  3. Catalytic Mechanism of Calcium/calmodulin dependent protein kinase type II is influenced by the substrate sequence. Praseeda M., Pradeep K. K., Leena S., Rajeev Kumar R., Mayadevi M., and Omkumar R V Poster presentation by Praseeda M. at the Gordon Research Conference on “Excitatory Amino Acids and Brain Function”, June 26-July 04, 2003, at Mount Holyoke College, Massachusetts, USA
  4. Studies on CaMKII-NMDA receptor Interactions. Omkumar R V, Praseeda M., Pradeep K. K., Leena S., Santhosh Kumar K., and Mayadevi M. Oral presentation by Omkumar R V at the XIX Annual Meeting of the Indian Academy of Neuroscience, March 18-20, 2002 held at the Indian Institute of Chemical Biology, Calcutta, INDIA.
  5. Sequence Determinants on the NR2A and NR2B subunits of the NMDA-type glutamate receptor that cause differential binding by Calcium/Calmodulin dependent protein kinase type II. Omkumar R V, Praseeda M., Kumar K. S., and Mayadevi M. Poster presentation by Omkumar R V at the Gordon Research Conference on “Cell Biology of the Neuron” June 18-June 23, 2000, held at Plymouth State College, Plymouth, NH, USA.
Patents
Title of the Invention : "Assay for detection of transient intracellular Ca2+".
Inventors : Omkumar, R. V., Rajeevkumar, R., Mathew Steephan, Mayadevi, M. and Suma Priya, S.
Countries filed : India, Europe and USA
PCT application filing No. : PCT/IN08/000370 dated 12-06-2008
Indian patent filing No. : 1276/CHE/2007 dated 06-06-2008