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Vibrio cholerae causes the life threatening diarrhoeal disease cholera. Cholera is a major public health problem in many developing countries including India, because of its transmissibility and its ability to occur in epidemic and pandemic forms. V.cholerae is a successful pathogen well adapted to various environmental niches. The molecular characteristics of environmental strains of V.cholerae are not properly understood.
The frequent outbreaks of cholera in Kerala have been reported in the past. As V.cholerae is a natural inhabitant of aquatic system, the study of environmental strains with respect to the virulence and multiple drug resistance becomes necessary.
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Another area we are focusing on is metagenomics. The study will help in unraveling the genomes of thousands of uncultivable bacteria which are hitherto unknown to science. They may carry information for several biomolecules which will help mankind to fight against dreaded diseases and have several other applications. Harnessing the knowledge of microbial interactions will help improve human health, food security, and energy production. The studies may also throw light on novel genes for biodegradation which will help in the degradation of recalcitrant xenobiotics and to keep the environment clean from pollution.
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Cholera & Environmental Biology |
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