The main object of the invention is to synthesis the novel class of gel-like dendrimer polymeric resins with high chemical, mechanical stability. So to rectifying all the existing defects and drawbacks of PS-DVB resin and other hydrophobic resins, the present work aim to introduce flexible PEG chains as dendrimer sites to hydrophobic resins through novel attachment patterns. The attachment of multiple dendritic PEG units to the hydrophobic system makes it completely solvent like gel. The main advantage of the proposed resins is due to its high functional loading and biocompatibility compared with known, national and international PEG-based resins.

Tuberculosis (T.B) is considered as the world’s foremost cause of death from a single infectious agent (Mycobacterium tuberculae) and around 80% of the tuberculosis originates as pulmonary tuberculosis. Mycobacterium tuberculae (Mtb) has the capability of resisting host defence mechanism. After entering in to alveolar macrophages they check the phagolysosomal fusion and further the Mtb multiplies inside the phagosome. This phenomenon helps in the cyclic reinfection of host macrophages by Mtb, allowing prolonged survival of the organism. The conventional treatment of tuberculosis is least patient compliant but chances of relapse are also high hence an inhalable delivery system which deliver the drugs directly to the site of infection may be an efficient method for treating pulmonary tuberculosis. Our present study includes the synthesis of novel inert carriers (excipients) using biocompatible and biodegradable polymers which will be further formulated in to drug loaded dry powder inhalable (DPI) system.

Nanoparticle can improve the bioavailabity of poorly absorbed drugs and nanoparticles are able to penetrate cells for cellular internalization and connective tissue penetration and so deliver the drug efficiently to the targeted tissue. The treatment of diseases not only requires the development and testing of new drugs, but also the minimization of their adverse effects without impairing the quality of life of the patient. Controlled drug delivery is a promising method in this field. It occurs when a polymer, whether natural or synthetic, is judiciously combined with a drug in such a way that the drug is released in a predesigned manner. It helps in achieving more effective therapies by eliminating the potential for both under and overdosing. Other advantages include the maintenance of drug levels within desired range, the need for fewer administrations, and increased patient compliance. In this area I am trying to develop novel biodegrading polymer nanoparticles and polymer film based implant for controlled drug delivery applications in cancer.

The main goal of the work is to develop a polymeric delivery system for drug, 5-Flurouracil devoid of adverse effects in colorectal cancer. Biodegradable polymers and copolymers based nanoparticle oral drug delivery system have been planed as the present work for drug targeting in colon cancer. The synthesized particles will be characterized by physicochemical properties and further evaluation will be done by suitable In-vitro and In-vivo models.

Gene therapy for cancer implies that ideally selective tumor cell killing or inhibition of tumor cell growth using nucleic acids as the therapeutic agent. Therefore, majority of cancer gene therapy strategies introduce foreign genes into tumor cells which aim at the immunological recognition and destruction of the target cells or the interference with tumor growth. The deliveries of therapeutic genes to cancer cells possess the greatest challenge to the successful application of cancer gene therapy in humans. As such, considerable effort is being devoted to the development of more selective and efficient vectors. The aim of our present work is to develop a delivery vector to protect the therapeutic genes from enzymatic degradation, facilitating cellular uptake and releasing gene at the site of action inside the tumor cells thereby silencing the malignant genes. The developments of systems that allow specific delivery of genes represent a great advance. This approach allows the applied doses to be smaller and avoids possible side effects in other tissues. Polymeric nanoparticles can achieve specific targeting to the tumor cells. Here we are incorporating hydrophobic properties and biocompatibility of some polymers to extend the half life of therapeutic genes in the blood stream.

The main goal of the proposed work is to develop a polymeric delivery system for paclitaxel and curcumin, capable of increasing the therapeutic index of the drug, devoid of adverse effects. Biodegradable Polyethyleneglycol (PEG) coated nanoparticles have been found to possess important potential therapeutic applications as injectable colloidal systems for the controlled release of drugs and site-specific drug delivery. Here we incorporate two properties to increase the long term circulation of polymer nanoparticles to reach the tumor tissue, with specific recognition capacity.

The main goal of the proposed work is to develop a polymeric delivery system for paclitaxel and curcumin, capable of increasing the therapeutic index of the drug, devoid of adverse effects. Biodegradable Polyethyleneglycol (PEG) coated naoparticles have been found to posses important potential therapeutic applications as injectable colloidal systems for the controlled release of drugs and site-specific drug delivery. Here we are incorporating two properties to increase the long term circulation of polymer nanoparticles to reach the tumor tissue, with specific recognition capacity.