Peer reviewed

1. Bhavya BC, Deepa I, Mahendra Seervi, Jeena Joseph, Praveen K Sobhan, Krupa AM, Saneesh Varghese, Santhoshkumar TR ,Endoplasmic reticulum targeted Bcl-2 inhibitable mitochondrial fragmentation initiated ER stress induced cell death, , J Exp Biol (In press)
2. Mohana Kumara P, Zuehlke S, Priti V, Ramesha BT, Shweta S, Ravikanth G, Vasudeva R, Santhoshkumar TR, Spiteller M, Uma Shaanker R. Fusarium proliferatum, an endophytic fungus from Dysoxylum binectariferum Hook.f, produces rohitukine, a chromane alkaloid possessing anti-cancer activity. Antonie Van Leeuwenhoek. 2011 Sep 4 (In press) DOI: 10.1007/s10482-011-9638-2
3. Mahendra Seervi, Jeena Joseph, Praveen K Sobhan, Bhavya BC, T R Santhosh Kumar, Essential Requirement of cytochrome c release for caspase activation by procaspase activating compound defined by cellular models”, Cell Death Dis. 2011 Sep 8;2:e207. doi: 10.1038/cddis.2011.90
4. Santhi Achuthan, T. R. Santhoshkumar, Jem Prabhakar, S. Asha Nair and M. Radhakrishna Pillai,Drug induced senescence generates chemoresistant stem like cells with low reactive oxygen species, JBC. Published on August 30, 2011 as Manuscript M110.200675, http://www.jbc.org/cgi/doi/10.1074/jbc.M110.200675
5. S Sreeja, B S Lakshmi, T R Santhosh Kumar, S Sreeja. Pomegranate extract demonstrate a selective estrogen receptor modulator profile in human tumor cell lines and in vivo models of estrogen deprivation. Journal of Nutritional Biochemistry, DOI :10.1016/j.nutbio.2011.03.015
6. Sathish Kumar Maney, Ann Mary Johnson, A Sampath Kumar, Vineet Nair, T R Santhosh Kumar, C C Kartha;Effect of Apoptosis-Inducing Antitumor Agents on Endocardial Endothelial Cells., June 2011, DOI: 10.1007/s12012-011-9119-x
7. Jeena Joseph, Mahendra Seervi, Praveen K Sobhan, Santhoshkumar TR, High Throughput Ratio Imaging to Profile Caspase Activity: Potential Application in Multiparameter High Content Apoptosis Analysis and Drug Screening, PLoS ONE, 2011, 6(5): e20114 doi: 10.1371/journal.pone.0020114
8. Bhavya Balan Chandrikaa, Sathish Kumar Maneya, Swathi U. Lekshmia and Santhoshkumar TR, Endoplasmic reticulum targeted Bcl2 confers long term cell survival through phosphorylation of heat shock protein 27 . The International Journal of Biochemistry & Cell Biology Volume 42, Issue 12, December 2010, 1984-1992
9. NJ. Merlin, V. Parthasarathy and T R. Santhoshkumar , Induction of apoptosis in human breast cancer cell line MCF-7 by phytochemicals from Gmelina asiatica,Afr.J. Biotechnology Vol. 9 (28), pp. 4451-4456, 12 July, 2010.
10. Bhavya Balan Chandrika, Sathish Kumar Maney, Swathi U. Lekshmi, Jeena Joseph,Mahendra Seervi, Praveen KS., Santhoshkumar T.R. Bax deficiency mediated drug resistance can be reversed by endoplasmic Reticulum stress induced death signaling , Biochemical Pharmacology 2010 Jun 1; 79(11):1589-99.
11. Joy, RajeevS, EmiliaA, MohanJohn, Praveen.KS, MahendraSeervi, SanthoshkumarT.R., Lysosomal Destabilization and CathepsinB Contributes for Cytochrome C Release and Caspase activation in embelin induced apoptosis. Mol.Carcinogenesis;;2010 Apr;49(4):324-36.
12. Mohanakumar,P, SreejayanN, PritiV, RameshaBT, RavikanthG, GaneshaiahKN, VasudevaR, MohanJ, SanthoshkumarTR,MishraPD, RamV, ShaankerRU., DysoxylumbinectariferumHook.f(Meliaceae), a rich source of rohitukine. Fitoterapia. 2010 Mar;81(2):145-8.
13. Kaur S, Kumar TR, Uruno A, Sugawara A, Jayakumar K, Kartha CC.Genetic engineering with endothelial nitric oxide synthase improves functional properties of endothelial progenitor cells from patients with coronary artery disease: an in vitro study. Basic Res Cardiol. 2009 Nov;104(6):739-49
14. Raveendran R, Devi Suma Priya S, Mayadevi M, Steephan M, Santhoshkumar TR, Cheriyan J, Sanalkumar R, Pradeep KK, James J, Omkumar RV, Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin-dependent protein kinase II. . J Neurochem. 2009 Jul;110(1):92-105.
15. Paul BT, Babu MS, Santhoshkumar TR, Karunagaran D, Selvam GS, Brown K, Woo T, Sharma S, Naicker S, Murugesan R Biophysical evaluation of two red-shifted hypocrellin B derivatives as novel PDT agents. .J Photochem Photobiol B. 2009 Jan 9;94(1):38-44.
16. Kumar MA, Nair M, Hema PS, Mohan J, Santhoshkumar TR . Pinocembrin triggers Bax-dependent mitochondrial apoptosis in colon cancer cells . Mol Carcinog. 46(3):231-41 .2007 .
17. Kuruvilla L, Santhoshkumar T.R, Kartha CC . Immortalization and characterization of porcine ventricular endocardial endothelial cells. Endothelium. 14(1):35-43 .2007.
18. Karunagaran D, Jeena Joseph, Kumar TR, Cell growth regulation, Adv Exp Med Biol, 2007, 595:245-68
19. John Mohan, Gandhi A, Bhavya BC, Rashmi, R, Karunagaran D, Indu R, Santhoshkumar T.R. caspase-2 triggers bax - bak dependent and independent cell death in colon cancer cells treated with resveratrol . J. Biol. Chem. 281(26) 17599- 611 .2006.
20. Sengupta, S., Smitha S.L, Thomas, N.E., Santosh, T.R., Devi, C., Sreejalekshmi, K.G. and Rajasekharan, K.N. DAT1, A cytotoxic agent towards cancer cells and a probe for tubulin microtubule system . British J Pharmacology 145,1076-1083. 2005.
21. Karunagaran, R. Rashmi and Santhosh Kumar T R.Induction of Apoptosis by Curcumin and Its Implications for Cancer Therapy.Current Cancer Drug Targets, 5, 117-129.2005.
22. Anshup J, Sai Venkataraman, Chandramouli Subramaniam, R. Rajeev Kumar, Suma Priya, T. R. Santhosh Kumar, R. V. Omkumar, Annie John, and T. Pradeep. Growth of Gold Nanoparticles in Human Cells. Langmuir 2005, 21, 11562-11567.
23. Rashmi R, Santhosh Kumar T R, Karunagaran D.Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL.Carcinogenesis, 26, 4, 713-723.2005.
24. Rashmi R, Santhosh Kumar T R, Karunagaran D. Ectopic expression of BclXL or Ku70 protects human colon cancer cellc SW 480 aginst curcumin induced apoptosis while their downregualtion potentiates it.,Carcinogenesis, Carcinogenesis vol.25 no.10 pp.1867--1877, 2004
25. Santhosh Kumar T R.Cytotoxicity and cell growth Assays in Biotechnique.Selvin J, Ninave A.S ( Eds) Biotech Consortia Tamil Nadu, India pp, 86-88.2003.
26. Sengupta, S., Smitha S.L, Thomas, N.E., Santhosh Kumar T R, Devi, C. and Rajasekharan, K.N.DAT1, A Novel Synthetic Microtubule Inhibitor, Exerts Cytotoxicity and Shows Efficacy Towards Multidrug Resistant Cancer Cell.,Mol. Biol. Cell (Suppln) 14, 183a.2003.
27. Santhosh Kumar T R, Mary Vasantha Bai, Lissy K Krishnan.A freeze-dried fibrin disc as a biodegradable drug release matrix.Biologicals 32, 1, 49-55.2004.
28. Rashmi R, Santhosh Kumar T R, Karunagaran D.Ectopic expression of hsp 70 confers resistance and silencing its expression sensitizes Human colon cancer cells to curcumin-induced apoptosis.Carcinogenesis, 25,2,179-187.2004.
29. Rashmi R, Santhosh Kumar T R, Karunagaran D.Human colon cancer cells differ in their sensitivity to curcumin induced apoptosis and heat shock protects them by inhibiting the release of apoptosis inducing factor.FEBS Lett.13.538, 19-24.2003.
30. Santhosh Kumar T R and Lissy K.Krishnan.Fibrin mediated endothelial cell adhesion to vascular biomaterials to resist shear stress due to flow.Mater.Science. Materials in Medicine.13, 1-5.2002.
31. Santhosh Kumar T R and Lissy K.Krishnan.A stable matrix for generation of tissue engineered non-thrombogenic vascular grafts.Tissue Engineering, 5, 763-70.2002.
32. Santhosh Kumar T R and Lissy K Krishnan.Endothelial cell growth factor enmeshed with polymerized fibrin to enhance proliferation of cell on polymeric materials.Biomaterials, 22, 2769-2776.2001.
33. Umashankar PR, Santhosh Kumar T R, Arthur Vijayan Lal.Modified Xylazine -Ketamine injectable anaesthesia by atropine sulfate Diazepam premedication in Rabbits for bone implantation.Trends in Biomaterials and artificial Organs, 1, 27-36.1996.
34. Santhosh Kumar T R, Umashankar PR, Arthur Vijayan Lal.Effect of oxygen supplementation under xylazine - Ketamine anaesthesia in adult rats.Trends in Biomaterials and artificial Organs, 1, 44-48.1996.